Evaluation of the hepatoprotective role of ethanolic Saussurea lappa root extract in female rats experimentally exposed to propylthiouracil

Propylthiouracil (PTU) is often used to produce experimental hypothyroidism. In general, PTU generates hepatotoxicity, albeit with dissimilar incidence rates of hepatotoxicity. This study examined the hepatoprotective effects Saussurea lappa root ethanol extract on experimentally induced hepatotoxicity in female rats. For this study, 25 adult albino rats were placed into five equal groups: control, PTU, post treated S. extract, co-administered 300mg/kg, and post-treated levothyroxine. Serum gamma-glutamyl transferase (GGT) activity, total protein, thyroid hormones (T3, T4, TSH), oxidative stress parameters (catalase, superoxide dismutase, reduced glutathione, lipid peroxidation levels) measured. The liver tissue underwent histological examination. Current findings revealed that S.lappa significantly improved as evidenced by reversal various biochemical histopathological changes has shown promising impact may be due antioxidant free radical scavenging characteristics constituents.